References

Akobeng AK. Understanding randomised controlled trials. Arch Dis Childhood. 2005; 90:(8)840-844 https://doi.org/10.1136/adc.2004.058222

Alves JC, Santos AM, Jorge PI. Effect of an oral joint supplement when compared to Carprofen in the Management of hip Osteoarthritis in working dogs. Topics Companion Anim Med. 2017; 32:(4)126-129 https://doi.org/10.1053/j.tcam.2017.10.003

Anderson KL, O'Neill DG, Brodbelt DC Prevalence, duration and risk factors for appendicular osteoarthritis in a UK dog population under primary veterinary care. Sci Rep. 2018; 8:(1)1-12 https://doi.org/10.1038/s41598-018-23940-z

Aragon CL, Hofmeister EH, Budsberg SC. Systematic review of clinical trials of treatments for osteoarthritis in dogs. J Amer Vet Med Assoc. 2007; 230:(4)514-521 https://doi.org/10.2460/javma.230.4.514

Baltzer WI, Smith-Ostrin S, Warnock JJ, Ruaux CG. Evaluation of the clinical effects of diet and physical rehabilitation in dogs following tibial plateau leveling osteotomy. J Amer Vet Med Assoc. 2018; 252:(6)686-700 https://doi.org/10.2460/javma.252.6.686

Beale BS. Use of nutraceuticals and chondroprotectants in osteoarthritic dogs and cats. Vet Clin North Amer. Small Anim Pract. 2004; 34:(1)271-289 https://doi.org/10.1016/j.cvsm.2003.09.008

Bhathal A, Spryszak M, Louizos C, Frankel G. Glucosamine and chondroitin use in canines for osteoarthritis: a review. Open Vet J. 2017; 7:(1)36-49 https://doi.org/10.4314/ovj.v7i1.6

Brown D, Boston R, Farrar J. Comparison of force plate gait analysis and owner assessment of pain using the canine brief pain inventory in dogs with osteoarthritis. J Vet Intern Med. 2013; 27:(1)22-30 https://doi.org/10.1111/jvim.12004

Calder PC, Zurier RB. Polyunsaturated fatty acids and rheumatoid arthritis. Curr Opin Clin Nutr Metab Care. 2001; 4:(2)115-121 https://doi.org/10.1097/00075197-200103000-00006

Cockcroft P, Holmes M. Handbook of evidence-based veterinary medicine.Hoboken (NJ): John Wiley and Sons; 2008

Comblain F, Serisier S, Barthelemy N, Balligand M, Henrotin Y. Review of dietary supplements for the management of osteoarthritis in dogs in studies from 2004 to 2014. J Vet Pharmacol Therap. 2016; 39:(1)1-15 https://doi.org/10.1111/jvp.12251

Comblain F, Barthélémy N, Lefèbvre M A randomized, double-blind, prospective, placebo-controlled study of the efficacy of a diet supplemented with curcuminoids extract, hydrolyzed collagen and green tea extract in owner's dogs with osteoarthritis. BMC Vet Res. 2017; 13:(1) https://doi.org/10.1186/s12917-017-1317-8

Conzemius MG, Evans RB. Caregiver placebo effect for dogs with lameness from osteoarthritis. J Amer Vet Med Assoc. 2012; 241:(10)1314-1319 https://doi.org/10.2460/javma.241.10.1314

Curtis CL, Hughes CE, Flannery CR n-3 fatty acids specifically modulate catabolic factors involved in articular cartilage degradation. J Biol Chem. 2000; 275:(2)721-724 https://doi.org/10.1074/jbc.275.2.721

DeFelice SL. The nutraceutical revolution: its impact on food industry R&D. Trends Food Sci Technol. 1995; 6:(2)59-61 https://doi.org/10.1016/S0924-2244(00)88944-X

Dobenecker B, Beetz Y, Kienzle E. A placebo-controlled double-blind study on the effect of nutraceuticals (chondroitin sulfate and mussel extract) in dogs with joint diseases as perceived by their owners. J Nutr. 2002; 132:(6)1690S-1691S https://doi.org/10.1093/jn/132.6.1690S

Eason CT, Adams SL, Puddick J Greenshell™ mussels: a review of veterinary trials and future research directions. Vet Sci. 2018; 5:(2) https://doi.org/10.3390/vetsci5020036

Fritsch D, Allen T, Dodd C Dose-titration effects of fish oil in osteoarthritic dogs. J Vet Inter Med. 2010a; 24:(5)1020-1026 https://doi.org/10.1111/j.1939-1676.2010.0572.x

Fritsch DA, Allen TA, Dodd CE A multicenter study of the effect of dietary supplementation with fish oil omega-3 fatty acids on carprofen dosage in dogs with osteoarthritis. J Amer Vet Med Assoc. 2010b; 236:(5)535-539 https://doi.org/10.2460/javma.236.5.535

Gamble L-J, Boesch JM, Frye CW Pharmacokinetics, safety, and clinical efficacy of cannabidiol treatment in osteoarthritic dogs. Front Vet Sci. 2018; 5 https://doi.org/10.3389/fvets.2018.00165

Glasziou P, Irwig L, Bain C, Colditz G. Systematic reviews in health care: a practical guide.Cambridge: Cambridge University Press; 2001

Halsted CH. Dietary supplements and functional foods: 2 sides of a coin?. Amer J Clin Nutr. 2003; 77:(4)1001S-1007S https://doi.org/10.1093/ajcn/77.4.1001S

Henrotin Y, Clutterbuck A, Allaway D Biological actions of curcumin on articular chondrocytes. Osteoarthritis Cartilage. 2010; 18:(2)141-149 https://doi.org/10.1016/j.joca.2009.10.002

Henrotin Y, Lambert C. Chondroitin and glucosamine in the management of osteoarthritis: an update. Curr Rheumatol Rep. 2013; 15:(10) https://doi.org/10.1007/s11926-013-0361-z

Hielm-Björkman A, Tulamo R-M, Salonen H, Raekallio M. Evaluating complementary therapies for canine osteoarthritis part I: green-lipped mussel (Perna canaliculus). Evid-Based Compl Alternative Med. 2009; 6:(3)365-373 https://doi.org/10.1093/ecam/nem136

Hielm-Björkman A, Roine J, Elo K An un-commissioned randomized, placebo-controlled double-blind study to test the effect of deep sea fish oil as a pain reliever for dogs suffering from canine OA. BMC Vet Res. 2012; 8:(1) https://doi.org/10.1186/1746-6148-8-157

Innes J, Fuller C, Grover E, Kelly A, Burn J. Randomised, double-blind, placebocontrolled parallel group study of P54FP for the treatment of dogs with osteoarthritis. Vet Rec. 2003; 152:(15)457-460 https://doi.org/10.1136/vr.152.15.457

Innes JF, Clayton J, Lascelles BDX. Review of the safety and efficacy of long-term NSAID use in the treatment of canine osteoarthritis. Vet Rec. 2010; 166:(8)226-230 https://doi.org/10.1136/vr.c97

Innes J, Tobias K, Johnston S. Veterinary surgery: small animal.St. Louis, MO: Elsevier Saunders; 2018

Lascelles BDX. Feline degenerative joint disease. Vet Surg. 2010; 39:(1)2-13 https://doi.org/10.1111/j.1532-950X.2009.00597.x

Maione S, Piscitelli F, Gatta L Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action. Br J Pharmacol. 2011; 162:(3)584-596 https://doi.org/10.1111/j.1476-5381.2010.01063.x

McCarthy G, O'Donovan J, Jones B Randomised double-blind, positive-controlled trial to assess the efficacy of glucosamine/chondroitin sulfate for the treatment of dogs with osteoarthritis. Vet J. 2007; 174:(1)54-61 https://doi.org/10.1016/j.tvjl.2006.02.015

Moreau M, Dupuis J, Bonneau N, Desnoyers M. Clinical evaluation of a nutraceutical, carprofen and meloxicam for the treatment of dogs with osteoarthritis. Vet Rec. 2003; 152:(11)323-329 https://doi.org/10.1136/vr.152.11.323

Paster ER, Lafond E, Biery DN Estimates of prevalence of hip dysplasia in Golden Retrievers and Rottweilers and the influence of bias on published prevalence figures. J Amer Vet Med Assoc. 2005; 226:(3)387-392 https://doi.org/10.2460/javma.2005.226.387

Rialland P, Bichot S, Lussier B Effect of a diet enriched with green-lipped mussel on pain behavior and functioning in dogs with clinical osteoarthritis. Can J Vet Res. 2013; 77:66-74

Roush JK, Cross AR, Renberg WC Evaluation of the effects of dietary supplementation with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis. J Amer Vet Med Assoc. 2010a; 236:(1)67-73 https://doi.org/10.2460/javma.236.1.67

Roush JK, Dodd CE, Fritsch DA Multicenter veterinary practice assessment of the effects of omega-3 fatty acids on osteoarthritis in dogs. J Amer Vet Med Assoc. 2010b; 236:(1)59-66 https://doi.org/10.2460/javma.236.1.59

Sanderson S. The epidemic of canine obesity and its role in osteoarthritis. Israel J Vet Med. 2012; 67:195-202

Santini A, Cammarata SM, Capone G Nutraceuticals: opening the debate for a regulatory framework. Br J Clin Pharmacol. 2018; 84:(4)659-672 https://doi.org/10.1111/bcp.13496

Singh JA, Noorbaloochi S, Macdonald R, Maxwell LJ. Chondroitin for osteoarthritis. Cochrane Database Syst Rev. 2015; 28:(1) https://doi.org/10.1002/14651858.cd005614.pub2

Vandeweerd JM, Coisnon C, Clegg P Systematic review of efficacy of nutraceuticals to alleviate clinical signs of osteoarthritis. J Vet Intern Med. 2012; 26:(3)448-456 https://doi.org/10.1111/j.1939-1676.2012.00901.x

Vasseur PB, Johnson A, Budsberg S Randomized, controlled trial of the efficacy of carprofen, a nonsteroidal anti-inflammatory drug, in the treatment of osteoarthritis in dogs. J Amer Vet Med Assoc. 1995; 206:(6)807-811

Verpaalen VD, Baltzer WI, Smith-Ostrin S Assessment of the effects of diet and physical rehabilitation on radiographic findings and markers of synovial inflammation in dogs following tibial plateau leveling osteotomy. J Amer Vet Med Assoc. 2018; 252:(6)701-709 https://doi.org/10.2460/javma.252.6.701

Verrico CD, Wesson S, Konduri V A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain. Pain. 2020; 161:(9)2191-2202 https://doi.org/10.1097/j.pain.0000000000001896

Walton MB, Cowderoy E, Lascelles D, Innes JF. Evaluation of construct and criterion validity for the ‘Liverpool Osteoarthritis in Dogs’(LOAD) clinical metrology instrument and comparison to two other instruments. PLoS One. 2013; 8:(3) https://doi.org/10.1371/journal.pone.0058125

Wandel S, Jüni P, Tendal B Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis. BMJ. 2010; 341:(sep16 2)c4675-c4675 https://doi.org/10.1136/bmj.c4675

Nutraceutical use in osteoarthritic canines: a review

02 July 2021
9 mins read
Volume 26 · Issue 7

Abstract

Osteoarthritis is prevalent in the UK canine population and has a clear impact on animal welfare. Treatment of osteoarthritis is advised to be multimodal, with nutraceuticals becoming a popular part of this approach. However, veterinary nutraceuticals are not subject to any regulation and systematic reviews are still uncommon in the veterinary field, which makes evaluating these products difficult. This article looks at the most commonly used veterinary supplements and how to critically evaluate the evidence of their efficacy. Evidence is promising for omega-3 fatty acids but is limited for other common ingredients. There are limited numbers of rigorous, randomised controlled trials and veterinary studies are often hampered by small sample sizes. Standardisation of reporting, as performed in human medicine, is needed to allow more robust systematic reviews of nutraceuticals to subsequently enable vets to make more informed decisions.

Osteoarthritis is a condition that every first opinion vet will have frequently encountered. Prevalence rates in published papers have varied wildly, with most reporting between 20 and 30% of the canine population aged over 1 year displaying some radiographic degree of osteoarthritis (Paster et al, 2005; Aragon et al, 2007; Comblain et al, 2016) and up to 40% of all cats being affected clinically, increasing to 90% of cats over 12 years of age (Lascelles, 2010).

The largest study of osteoarthritis in dogs under veterinary care was conducted recently by VetCompass, covering 455 557 dogs. The results showed a lower prevalence of 2.5% of dogs being recorded with clinical and or radiographic signs of osteoarthritis in 2013 (Anderson et al, 2018). However, this still equates to 200 000 affected dogs in the UK annually. By looking at the frequency, duration and severity of clinical signs all together, osteoarthritis was found to be one of three conditions that had the highest welfare impact overall on dogs. Obesity was one of the other top three conditions affecting animal welfare and it is worth noting that overweight dogs had 2.3 times the risk of developing osteoarthritis.

Register now to continue reading

Thank you for visiting UK-VET Companion Animal and reading some of our peer-reviewed content for veterinary professionals. To continue reading this article, please register today.