References

Aguirre A. Gallbladder mucocele, 8th edn. In: Ettinger SJ, Feldman FC, Côté E (eds). St. Louis, Missouri: Elsevier; 2017

Aguirre AL, Center SA, Randolph JF Gallbladder disease in Shetland Sheepdogs: 38 cases (1995-2005). J Am Vet Med Assoc. 2007; 231:(1)79-88 https://doi.org/10.2460/javma.231.1.79

Allerton F, Swinbourne F, Barker L Gall bladder mucoceles in Border terriers. J Vet Intern Med. 2018; 32:(5)1618-1628 https://doi.org/10.1111/jvim.15249

Bennett SL, Milne M, Slocombe RF, Landon BP. Gallbladder mucocele and concurrent hepatic lipidosis in a cat. Australian Vet J. 2007; 85:(10)397-400 https://doi.org/10.1111/j.1751-0813.2007.00182.x

Besso JG, Wrigley RH, Gliatto JM, Webster CRL. Ultrasonographic appearance and clinical findings in 14 dogs with gallbladder mucocele. Vet Radiol Ultrasound. 2000; 41:(3)261-271 https://doi.org/10.1111/j.1740-8261.2000.tb01489.x

Brand EM, Lim CK, Heng HG Computed tomographic features of confirmed gallbladder pathology in 34 dogs. Vet Radiol Ultrasound. 2020; 61:(6)667-613 https://doi.org/10.1111/vru.12909

Center S. Diseases of the gallbladder and biliary Tree. Vet Clin North Am Small Anim Pract. 2009; 39:(3)543-598 https://doi.org/10.1016/j.cvsm.2009.01.004

Choi J, Kim A, Keh S Comparison between ultrasonographic and clinical findings in 43 dogs with gallbladder mucoceles. Vet Radiol Ultrasound. 2014; 55:(2)202-207 https://doi.org/10.1111/vru.12120

Crews LJ, Feeney DA, Jessen CR, Rose ND, Matise I. Clinical, ultrasonographic, and laboratory findings associated with gallbladder disease and rupture in dogs: 45 cases (1997–2007). JAVMA. 2009; 234:(3)359-366 https://doi.org/10.2460/javma.234.3.359

DeMonaco SM, Grant DC, Larson MM Spontaneous course of biliary sludge over 12 months in dogs with ultrasonographically identified biliary sludge. J Vet Intern Med. 2016; 30:(3)771-778 https://doi.org/10.1111/jvim.13929

Evans H, de Lahunta A. Bile passages and gallbladder. In: Evans H, de Lahunta A c (eds). St. Louis, Missouri: Elsevier; 2013

Jaffey JA, Pavlick M, Webster CR Effect of clinical signs, endocrinopathies, timing of surgery, hyperlipidemia, and hyperbilirubinemia on outcome in dogs with gallbladder mucocele. Vet J. 2019; 251:105350-105359 https://doi.org/10.1016/j.tvjl.2019.105350

Jüngst D. Mucin and phospholipids determine viscosity of gallbladder bile in patients with gallstones. World J Gastroenterol. 2001; 7:(2)203-207 https://doi.org/10.3748/wjg.v7.i2.203

Kanemoto H, Sakai M, Sakamoto Y American Cocker Spaniel chronic hepatitis in Japan. J Vet Intern Med. 2013; 27:(5)1041-1048 https://doi.org/10.1111/jvim.12126

Kook PH, Schellenberg S, Rentsch KM Effects of iatrogenic hypercortisolism on gallbladder sludge formation on biochemical bile constituents in dogs. Vet J. 2012; 191:(2)225-230 https://doi.org/10.1016/j.tvjl.2011.01.004

Kutsunai M, Kanemoto H, Fukushima K The association between gall bladder mucoceles and hyperlipidemias in dogs: a retrospective case control study. Vet J. 2014; 199:(1)76-79 https://doi.org/10.1016/j.tvjl.2013.10.019

Lindaberry C, Vaden S, Aicher KM Proteinuria in dogs with gallbladder mucocele formation: a retrospective case control study. J Vet Intern Med. 2021; 35:(2)878-886 https://doi.org/10.1111/jvim.16051

Malek S, Sinclair E, Hosgood G Clinical findings and prognostic factors for dogs undergoing cholecystectomy for gall bladder mucocele. Vet Surg. 2013; 42:(4)418-426 https://doi.org/10.1111/j.1532-950X.2012.01072.x

Moores A, Gregory S. Duplex gall bladder associated with choledocholithiasis, cholecystitis, gall bladder rupture and septic peritonitis in a cat. J Small Animal Practice. 2007; 48:(7)404-409 https://doi.org/10.1111/j.1748-5827.2006.00268.x

Norwich A. Gallbladder mucocele in a 12-year-old Cocker Spaniel. Can Vet J. 2011; 52:(3)319-321

Parakanzky M Long-term survival of dogs treated for gallbladder mucocele by cholecystectomy, medical management, or both. J Vet Internal Med. 2019; 33:2057-2066 https://doi.org/10.1111/jvim.15611

Pavlick M, DeLaforcade A, Penninck DG, Webster CRL. Evaluation of coagulation parameters in dogs with gallbladder mucoceles. J Vet Intern Med. 2021; 35:(4)1763-1772 https://doi.org/10.1111/jvim.16203

Pike FS, Berg J, King NW Gallbladder mucocele in dogs: 30 cases (2000-2002. J Am Vet Med Assoc. 2004; 224:(10)1615-1622 https://doi.org/10.2460/javma.2004.224.1615

Rogers E, Jaffey JA, Graham A Prevalence and impact of cholecystitis on outcome in dogs with gallbladder mucocele. JVECC. 2020; 30:(1)97-95 https://doi.org/10.1111/vec.12910

Samuelson D., 1st edn. Philadelphia (PA): Saunders Co; 2006

Tsukagoshi T, Ohno K, Tsukamoto A Decreased gallbladder emptying in dogs with biliary sludge or gallbladder mucoceles. Vet Radiol Ultrasound. 2012; 53:(1)84-91 https://doi.org/10.1111/j.1740-8261.2011.01868.x

Wennogle SA, Randall EK, Priestnall SL Eubacterial fluorescence in situ hybridisation and histologic features in 25 dogs with gallbladder mucocele. J Small Anim Pract. 2019; 60:(5)291-297 https://doi.org/10.1111/jsap.12982

Woods K, Brisson BDA, Olbak M. Congenital duplex gallbladder and biliary mucocele associated with partial hepatic cholestasis and cholelithiasis in a cat. Can Vet J. 2012; 53:(3)269-273

Worley D, Hottinger H, Lawrence H. Surgical management of gallbladder mucoceles in dogs: 22 cases (1999–2003). JAVMA. 2004; 224:(9)1418-1422

A review of gallbladder mucocele – part 1: aetiopathogenesis and diagnosis

02 June 2022
7 mins read
Volume 27 · Issue 6
Figure 2. a) Marked amount of echogenic bile positioned centrally in the gall bladder surrounded by thin hypoechoic rim. b) Moderate amount of mildly organised echogenic bile centrally positioned in the gall bladder surrounded by thick hypoechoic rim. c) Mildly heterogenous well organised echogenic bile that occupies the entire gallbladder lumen. d) Echogenic bile organised into a typical stellate pattern characterised by radiating hyperechoic striations alternated by anechoic bile.
Figure 2. a) Marked amount of echogenic bile positioned centrally in the gall bladder surrounded by thin hypoechoic rim. b) Moderate amount of mildly organised echogenic bile centrally positioned in the gall bladder surrounded by thick hypoechoic rim. c) Mildly heterogenous well organised echogenic bile that occupies the entire gallbladder lumen. d) Echogenic bile organised into a typical stellate pattern characterised by radiating hyperechoic striations alternated by anechoic bile.

Abstract

Gallbladder mucocele is defined as a build-up of immobile mucus within the gallbladder that can result in extrahepatic biliary obstruction, pressure necrosis of the gallbladder wall and ultimately, rupture. The incidence of this disease has increased steadily in veterinary medicine and now it is one of the most recognised extrahepatic biliary tract problems in the dog. This is not likely to solely be a result of an increased incidence of the disease, but more so the increasingly widespread use of ultrasonography to diagnose it. There are several proposed causes and predisposing factors of gallbladder mucocele, including mechanical or functional obstruction of the cystic duct, idiopathic dyslipidaemias, glucocorticoid excess and cholecystitis. Although clinicopathological changes are often present, they are not specific to the disease and the gold standard diagnostic imaging tool is ultrasonography.

Gallbladder mucocele is defined as a build-up of immobile mucus within the gallbladder (Figure 1) that can result in extrahepatic biliary obstruction, pressure necrosis of the gallbladder wall and ultimately, rupture (Rogers et al, 2020). The rate at which dogs present with this disease has been steadily increasing and it is now one of the most commonly recognised extrahepatic biliary tract problems in the dog (Aguirre, 2017). Gallbladder mucoceles in cats are very rare and to the author's knowledge, have only been reported in the veterinary literature three times (Bennett et al, 2007; Moores and Gregory, 2007; Woods et al, 2012). This low incidence may be because of the lower number of mucus glands within the gall bladder wall of a cat compared to the dog (Center, 2009).

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