References

Adams VJ, Campbell JR, Waldner CL, Dowling PM, Shmon CL Evaluation of client compliance with short-term administration of antimicrobials to dogs. J Am Vet Med Assoc. 2005; 226:567-574 https://doi.org/10.2460/javma.2005.226.567

Agel J, Evans AR, Marsh JL The OTA open fracture classification: a study of reliability and agreement. J Orthop Trauma. 2013; 27:(7)379-385 https://doi.org/10.1097/BOT.0b013e3182820d31

Ali AM, Noyes D, Cogswell LK Management of open fractures of the lower limb. Br J Hosp Med (Lond). 2013; 74:577-580 https://doi.org/10.12968/hmed.2013.74.10.577

Anderson JT, Gustilo RB Immediate internal fixation in open fractures. Orthop Clin North Am. 1980; 11:569-578 https://doi.org/10.1016/S0030-5898(20)31458-9

Anglen JO Comparison of soap and antibiotic solutions for irrigation of lower-limb open fracture wounds. A prospective, randomized study. J Bone Joint Surg [Am]. 2005; 87:(A)1415-1422

Bhandari M, Adili A, Lachowski RJ High pressure pulsatile lavage of contaminated human tibiae: an in vitro study. J Orthop Trauma. 1998; 12:(7)479-484 https://doi.org/10.1097/00005131-199809000-00009

Bhandari M, Adili A, Schemitsch EH The efficacy of low-pressure lavage with different irrigating solutions to remove adherent bacteria from bone. J Bone Joint Surg Am. 2001; 83:(3)412-419 https://doi.org/10.2106/00004623-200103000-00014

Bhandari M, Jeray KJ, Petrisor BA FLOW Investigators. A trial of wound irrigation in the initial management of open fracture wounds. N Engl J Med. 2015; 373:2629-2641 https://doi.org/10.1056/nejmoa1508502

Bosse MJ, Murray CK, Carlini AR METRC: Assessment of severe extremity wound bioburden at the time of definitive wound closure or coverage: Correlation with subsequent postclosure deep wound infection (METRC bioburden study. J Orthop Trauma. 2017; 31:S3-S9 https://doi.org/10.1097/BOT.0000000000000805

Brumback RJ, Jones AL Interobserver agreement in the classification of open fractures of the tibia. The results of a survey of two hundred and forty-five orthopaedic surgeons. J Bone Joint Surg Am. 1994; 76:(8)1162-1166 https://doi.org/10.2106/00004623-199408000-00006

Buchholz HW, Elson RA, Engelbrecht E, Roettger LH Management of deep infection of total hip replacement. J Bone Joint Surg Br. 1981; 63:342-353 https://doi.org/10.1302/0301-620X.63B3.7021561

Cai X, Han K, Cong X The use of calcium sulfate impregnated with vancomycin in the treatment of open fractures of long bones: a preliminary study. Orthopedics. 2010; 33:(3) https://doi.org/10.3928/01477447-20100129-17

Calhoun JH, Henry SL, Anger DM, Cobos JA, Mader JT The treatment of infected nonunions with gentamicin-polymethylmetacrylate antibiotic beads. Clin Orthop Relat Res. 1993; 295:23-27

Carsenti-Etesse H, Doyon F, Desplaces N Epidemiology of bacterial infection during management of open leg fractures. Eur J Clin Microbiol Infect Dis. 1999; 18:315-323 https://doi.org/10.1007/PL00015012

Cheng Q, Zhang XF, Di DH, Zhao GY, Cui XW Efficacy of different irrigation solutions on the early debridement of open fracture in rats. Exp Ther Med. 2015; 9:1589-1592 https://doi.org/10.3892/etm.2015.2325

Chiaramonti AM, Robertson AD, Nguyen TP Pulsatile lavage of musculoskeletal wounds causes muscle necrosis and dystrophic calcification in a rat model. J Bone Joint Surg Am. 2017; 99:1851-1858 https://doi.org/10.2106/JBJS.17.00330

Dudareva M, Kumin M, Vach W Short or long antibiotic regimes in orthopaedics (SOLARIO): a randomised controlled open-label non-inferiority trial of duration of systemic antibiotics in adults with orthopaedic infection treated operatively with local antibiotic therapy. Trials. 2019; 20 https://doi.org/10.1186/s13063-019-3832-3

Fischer MD, Gustilo RB, Varecka TF The timing of flap coverage, bone-grafting, and intramedullary nailing in patients who have a fracture of the tibial shaft with extensive soft-tissue injury. J Bone Joint Surg Am. 1991; 73:(9)1316-1322

Friedrich P Die aseptische Versorgung frischer wunden, unter mittheilung von their-versuchen uber die Auskeimungszeit von infectionserregem in frischen wunden. Arch Clin Chir. 1898;

Fuchs T, Stange R, Schmidmaier G, Raschke MJ The use of gentamicin-coated nails in the tibia: preliminary results of a prospective study. Arch Orthop Trauma Surg. 2011; 131:1419-1425 https://doi.org/10.1007/s00402-011-1321-6

Garner MR, Sethuraman SA, Schade MA, Boateng H Antibiotic prophylaxis in open fractures: evidence, evolving issues and recommendations. J Am Acad Orthop Surg. 2020; 28:(8)309-315 https://doi.org/10.5435/JAAOS-D-18-00193

Ghoshal A, Enninghorst N, Sisak K, Balogh ZJ An interobserver reliability comparison between the Orthopaedic Trauma Association's open fracture classification and the Gustilo and Anderson classification. Bone Joint J. 2018; 100B:(2)242-246 https://doi.org/10.1302/0301-620X.100B2.BJJ-2017-0367.R1

Godina M Early microsurgical reconstruction of complex trauma of the extremities. Plast Reconstr Surg. 1986; 78:285-292 https://doi.org/10.1097/00006534-198609000-00001

Govender S, Csimma C, Genant HK, Valentin-Opran A. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am. 2002; 84:2123-2134 https://doi.org/10.2106/00004623-200212000-00001

Gustilo RB, Anderson JT Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. J Bone Joint Surg Am. 1976; 58:(4)453-458 https://doi.org/10.2106/00004623-197658040-00004

Gustilo RB, Mendoza RM, Williams DN Problems in the management of type III (severe) open fractures: a new classification of type III open fractures. J Trauma. 1984; 24:(8)742-746 https://doi.org/10.1097/00005373-198408000-00009

Gustilo RB, Merkow RL, Templeman D The management of open fractures. J Bone Joint Surg Am. 1990; 72:(2)299-304

Halawi MJ, Morwood MP Acute management of open fractures: an evidence-based review. Orthopedics. 2015; 38:(11)E1025-33 https://doi.org/10.3928/01477447-20151020-12

Hao J, Cuellar DO, Herbert B Does the OTA open fracture classification predict the need for limb amputation? A retrospective observational cohort study on 512 patients. J Orthop Trauma. 2016; 30:(4)194-198 https://doi.org/10.1097/BOT.0000000000000479

Hardes J, Von EC, Streitbuerger A Reduction of periprosthetic infection with silver-coated megaprostheses in patients with bone sarcoma. J Surg Oncol. 2010; 1 01:389-395 https://doi.org/10.1002/jso.21498

Harry LE, Sandison A, Paleolog EM Comparison of the healing of open tibial fractures covered with either muscle or fasciocutaneous tissue in a murine model. J Orthop Res. 2008; 26:1238-1244 https://doi.org/10.1002/jor.20649

Helgeson CMD, Potter MBK, Tucker CCJ, Frisch LHM, Shawen LSB Antibiotic-impregnated calcium sulfate use in combat-related open fractures. Orthopedics. 2009; 32:(5) https://doi.org/10.3928/01477447-20090501-03

Hoad-Reddick DA, Evans CR, Norman P, Stockley I Is there a role for extended antibiotic therapy in a two-stage revision of the infected knee arthroplasty?. J Bone Joint Surg Br. 2004; 87:171-174 https://doi.org/10.1302/0301-620X.87B2.15640

Hoff WS, Bonadies JA, Cachecho R East practice management guidelines work group: update to practice management guidelines for prophylactic antibiotic use in open fractures. J Trauma. 2011; 70:(3)751-754 https://doi.org/10.1097/TA.0b013e31820930e5

Horn BD, Rettig ME Interobserver reliability in the Gustilo and Anderson classification of open fractures. J Orthop Trauma. 1993; 7:(4)357-360

Howlin RP, Brayford MJ, Webb JS Antibiotic-loaded synthetic calcium sulfate beads for prevention of bacterial colonization and biofilm formation in periprosthetic infections. Antimicrob Agents Chemother. 2015; 59:111-120 https://doi.org/10.1128/AAC.03676-14

Huddleston PM, Steckelberg JM, Hanssen AD, Rouse MS Ciprofloxacin inhibition of experimental fracture healing. J Bone Joint Surg Am. 2000; 82:161-173

Jenkinson RJ, Kiss A, Johnson S Delayed wound closure increases deep infection rate associated with lower-grade open fractures: a propensity-matched cohort study. J Bone Joint Surg Am. 2014; 96:(5)380-386 https://doi.org/10.2106/JBJS.L.00545

Klemm K The use of antibiotic-containing bead chains in the treatment of chronic bone infections. Clin Microbiol Infect. 2001; 7:23-31 https://doi.org/10.1046/j.1469-0691.2001.00186.x

Lack WD, Karunakar MA, Angerame MR Type III open tibia fractures: immediate antibiotic prophylaxis minimizes infection. J Orthop Trauma. 2015; 29:(1)1-6 https://doi.org/10.1097/BOT.0000000000000262

Lee J Efficacy of cultures in the management of open fractures. Clin Orthop Relat Res. 1997; 339:71-75 https://doi.org/10.1097/00003086-199706000-00010

Lenarz CJ, Watson JT, Moed BR Timing of wound closure in open fractures based on cultures obtained after debridement. J Bone Joint Surg [Am]. 2010; 92-A:1921-1926 https://doi.org/10.2106/jbjs.i.00547

Practice management guidelines for prophylactic antibiotic use in open fractures. 2000. http://www.east.org/education/practice-management-guidelines/open-fractures-prophylacticantibiotic-use-in-update (accessed 17 September 2021)

Madhuchandra P, Rafi M, Devadoss S, Devadoss A Predictability of salvage and outcome of Gustilo and Anderson type-IIIA and type-IIIB open tibial fractures using Ganga Hospital scoring system. Injury. 2015; 46:(2)282-287 https://doi.org/10.1016/j.injury.2014.11.003

McKee MD, Wild LM, Schemitsch EH The use of an antibiotic-impregnated, osteoconductive, bioabsorbable bone substitute in the treatment of infected long bone defects: early results of a prospective trial. J Orthop Trauma. 2002; 16:(9)622-627 https://doi.org/10.1097/00005131-200210000-00002

Messner J, Papakostidis C, Giannoudis PV, Kanakaris NK Duration of administration of antibiotic agents for open fractures: meta-analysis of the existing evidence. Surg Infect (Larchmt). 2017; 18:854-867 https://doi.org/10.1089/sur.2017.108

Metsemakers W, Reul M, Nijs S The use of gentamicin-coated nails in complex open tibia fracture and revision cases: a retrospective analysis of a single centre case series and review of the literature. Injury. 2015; 46:(12)2433-2437 https://doi.org/10.1016/j.injury.2015.09.028

Morgenstern M, Vallejo A, McNally M The effect of local antibiotic prophylaxis when treating open limb fractures: a systematic review and meta-analysis. Bone Joint Res. 2018; 7:(7)447-456 https://doi.org/10.1302/2046-3758.77.BJR-2018-0043.R1

Okike K, Bhattacharyya T Trends in the management of open fractures. A critical analysis. J Bone Joint Surg (Am). 2007; 88:2739-2748 https://doi.org/10.2106/00004623-200612000-00025

Olesen UK, Juul R, Bonde CT A review of forty-five open tibial fractures covered with free flaps. Analysis of complications, microbiology and prognostic factors. Int Orthop. 2015; 39:(6)1159-1166 https://doi.org/10.1007/s00264-015-2712-z

Olufemi OT, Adeyeye AI Irrigation solutions in open fractures of the lower extremities: evaluation of isotonic saline and distilled water. SICOT-J. 2017; 3 https://doi.org/10.1051/sicotj/2016031

Open fracture study group: a new classification scheme for open fractures. J Orthop Trauma. 2010; 24:457-464

Papich MG Antibiotic treatment of resistant infections in small animals. Vet Clin North Am Small Anim Pract. 2013; 43:1091-1097 https://doi.org/10.1016/j.cvsm.2013.04.006

Patzakis MJ, Harvey JP, Ivler D The role of antibiotics in the management of open fractures. J Bone Joint Surg Am. 1974; 56:(3)532-541

Patzakis MJ, Wilkins J Factors influencing infection rate in open fracture wounds. Clin Orthop Relat Res. 1989; (243)36-40

Patzakis MJ, Bains RS, Lee J Prospective, randomized, double-blind study comparing single-agent antibiotic therapy, ciprofloxacin, to combination antibiotic therapy in open fracture wounds. J Orthop Trauma. 2000; 14:(8)529-533 https://doi.org/10.1097/00005131-200011000-00002

Penn-Barwell JG, Murray CK, Wenke JC Early antibiotics and debridement independently reduce infection in an open fracture model. J Bone Joint Surg Br. 2012a; 94:(1)107-112 https://doi.org/10.1302/0301-620X.94B1.27026

Penn-Barwell JG, Murray CK, Wenke JC Comparison of the antimicrobial effect of chlorhexidine and saline for irrigating a contaminated open fracture model. J Orthop Trauma. 2012b; 26:(12)728-732 https://doi.org/10.1097/BOT.0b013e31826c19c4

Penn-Barwell JG, Murray CK, Wenke JC Local antibiotic delivery by a bioabsorbable gel is superior to PMMA bead depot in reducing infection in an open fracture model. J Orthop Trauma. 2014; 28:(6)370-375 https://doi.org/10.1097/BOT.0b013e3182a7739e

Peterson LC, Kim SE, Lewis DD Calcium sulfate antibiotic-impregnated bead implantation for deep surgical site infection with orthopedic surgery in small animals. Vet Surg. 2021; 50:(4)748-757 https://doi.org/10.1111/vsu.13570

Rajasekaran S, Babu JN, Dheenadhayalan J A score for predicting salvage and outcome in Gustilo type-IIIA and type-IIIB open tibial fractures. J Bone Joint Surg Br. 2006; 88:(10)1351-1360 https://doi.org/10.1302/0301-620X.88B10.17631

Rajasekaran S, Dheenadhayalan J, Babu JN Immediate primary skin closure in type-III A and B open fractures: results after a minimum of five years. J Bone Joint Surg Br. 2009; 91:(2)217-224 https://doi.org/10.1302/0301-620X.91B2.21228

Rajasekaran S, Giannoudis PV Open injuries of the lower extremity: issues and unknown frontiers. Injury. 2012; 43:(11)1783-1784 https://doi.org/10.1016/j.injury.2012.08.039

Rajasekaran S, Sabapathy SR A philosophy of care of open injuries based on the Ganga hospital score. Injury. 2007; 38:(2)137-146 https://doi.org/10.1016/j.injury.2006.04.135

Rupp M, Popp D, Alt V Prevention of infection in open fractures: Where are the pendulums now?. Injury. 2020; 51:(S2)S57-S63 https://doi.org/10.1016/j.injury.2019.10.074

Scharfenberger AV, Alabassi K, Smith S Primary wound closure after open fracture: a prospective cohort study examining nonunion and deep infection. J Orthop Trauma. 2017; 31:121-126 https://doi.org/10.1097/BOT.0000000000000751

Schenker ML, Yannascoli S, Baldwin KD, Ahn J, Mehta S Does timing to operative debridement affect infectious complications in open long-bone fractures? A systematic review. J Bone Joint Surg Am. 2012; 94-A:1057-64 https://doi.org/10.2106/JBJS.K.00582

Schmidmaier G, Lucke M, Wildemann B, Haas NP, Raschke M Prophylaxis and treatment of implant-related infections by antibiotic-coated implants: a review. Injury. 2006; 37:(2)S105-12 https://doi.org/10.1016/j.injury.2006.04.016

Schmidmaier G, Kerstan M, Schwabe P, Südkamp N, Raschke M Clinical experiences in the use of a gentamicin-coated titanium nail in tibia fractures. Injury. 2017; 48:(1)2235-2241 https://doi.org/10.1016/j.injury.2017.07.008

Shirai T, Tsuchiya H, Nishida H Antimicrobial megaprostheses supported with iodine. J Biomater Appl. 2014; 29:617-623 https://doi.org/10.1177/0885328214539365

Sørensen TS, Sørensen lI, Merser S Rapid release of gentamicin from collagen sponge: in vitro comparison with plastic beads. Acta Orthop. 1990; 61:(4)353-356 https://doi.org/10.3109/17453679008993535

Sprague S, Petrisor B, Jeray K Wound irrigation does not affect health-related quality of life after open fractures: results of a randomized controlled trial. Bone Joint J. 2018; 100-B:(1)88-94 https://doi.org/10.1302/0301-620X.100B1.BJJ-2017-0955.R1

Stockley I, Mockford BJ, Hoad-Reddick A, Norman P The use of two-stage exchange arthroplasty with depot antibiotics in the absence of long-term antibiotic therapy in infected total hip replacement. J Bone Joint Surg Br. 2008; 90B:(2)145-148 https://doi.org/10.1302/0301-620X.90B2.19855

Stravinskas M, Horstmann P, Ferguson J Pharmacokinetics of gentamicin eluted from a regenerating bone graft substitute. In vitro and clinical release studies. Bone Joint Res. 2016; 5:(9)427-435 https://doi.org/10.1302/2046-3758.59.BJR-2016-0108.R1

Swiontkowski MF Criteria for bone debridement in massive lower limb trauma. Clin Orthop Relat Res. 1989; (243)41-47

Swiontkowski MF, Aro HT, Donell S Recombinant human bone morphogenetic protein-2 in open tibial fractures: a subgroup analysis of data combined from two prospective randomized studies. J Bone Joint Surg Am. 2006; 88:(6)1258-1265 https://doi.org/10.2106/00004623-200606000-00013

Taggart T, Kerry RM, Norman P, Stockley I The use of vancomycin-impregnated cement beads in the management of infection of prosthetic joints. J Bone Joint Surg Br. 2002; 84:70-72 https://doi.org/10.1302/0301-620X.84B1.0840070

Templeman DC, Gulli B, Tsukayama DT Update on the management of open fractures of the tibial shaft. Clin Orthop Relat Res. 1998; 350:18-25

Tetsworth K, Cierny G Osteomyelitis debridement techniques. Clin Orthop Relat Res. 1999; 360:87-96 https://doi.org/10.1097/00003086-199903000-00011

Trompeter AJ, Furness H, Kanakaris NK, Costa ML Classification of open fractures: the need to modernize. Bone Joint J. 2020; 102-B:(11)1431-1434 https://doi.org/10.1302/0301-620X.102B11.BJJ-2020-0947

Trueta J Reflections on the past and present treatment of war wounds and fractures. Mil Med. 1976; 141:(4)255-258 https://doi.org/10.1093/milmed/141.4.255

Tsuchiya H, Shirai T, Nishida H Innovative antimicrobial coating of titanium implants with iodine. J Orthop Sci. 2012; 17:(5)595-604 https://doi.org/10.1007/s00776-012-0247-3

Van Moojen DJ, Hentenaar B, Vogely CH In vitro release of antibiotics from commercial PMMA beads and articulating hip spacers. J Arthroplast. 2008; 23:(8)1152-1156 https://doi.org/10.1016/j.arth.2007.08.020

Venkatadass K, Grandhi TSP, Rajasekaran S Use of Ganga Hospital open injury severity scoring for determination of salvage versus amputation in open type IIIB injuries of lower limbs in children - an analysis of 52 type IIIB open fractures. Injury. 2017; 48:(11)2509-2514 https://doi.org/10.1016/j.injury.2017.09.010

Werner CML, Pierpont Y, Pollak AN The urgency of surgical débridement in the management of open fractures. J Am Acad Orthop Surg. 2008; 16:(7)369-375 https://doi.org/10.5435/00124635-200807000-00002

Wilkins J, Patzakis M Choice and duration of antibiotics in open fractures. Orthop Clin North Am. 1991; 22:(3)433-437 https://doi.org/10.1016/S0030-5898(20)31673-4

Worlock P, Slack R, Harvey L The prevention of infection in open fractures: an experimental study of the effect of fracture stability. Injury. 1994; 25:(1)31-38 https://doi.org/10.1016/0020-1383(94)90181-3

Zajonz D, Birke U, Ghanem M Silver-coated modular Megaendoprostheses in salvage revision arthroplasty after periimplant infection with extensive bone loss–a pilot study of 34 patients. BMC Musculoskelet Disord. 2017; 18 https://doi.org/10.1186/s12891-017-1742-7

Zalavras CG, Patzakis MJ Open fractures: evaluation and management. J Am Acad Orthop Surg. 2003; 11:(3)212-219 https://doi.org/10.5435/00124635-200305000-00008

Zalavras CG, Marcus RE, Levin LS Management of open fractures and subsequent complications. J Bone Joint Surg Am. 2007; 89:(4)884-895 https://doi.org/10.2106/00004623-200704000-00027

Zalavras CG Prevention of infection in open fractures. Infect Dis Clin N Am. 2017; 31:339-352 https://doi.org/10.1016/j.idc.2017.01.005

Zelle BA, Boni G Safe surgical technique: intramedullary nail fixation of tibial shaft fractures. Patient Saf Surg. 2015; 9 https://doi.org/10.1186/s13037-015-0086-1

Emergency management of open fractures

02 November 2021
23 mins read
Volume 26 · Issue 10
Figure 4. Summary flow chart demonstrating the decision-making process regarding antibiosis in open fracture patients.
Figure 4. Summary flow chart demonstrating the decision-making process regarding antibiosis in open fracture patients.

Abstract

Open fractures are associated with an increased risk of complications, such as infection or nonunion, and present a therapeutic challenge. The incidence of such complications is directly influenced by how they are treated in the first several hours after presentation. As such, the focus of this article is to adopt an evidence-based approach to guide open fracture emergency management and minimise complication rates. Upon initial presentation, the potential for concomitant life-threatening injuries should be investigated and the patient stabilised as necessary. Critical components of emergency management that have been shown to impact on complication rates include initial classification of the fracture, the prompt instigation of broad-spectrum systemic antibiotic therapy, the use of local antibiotics in select cases and copious wound irrigation using sterile saline. As long as antibiosis is attended to appropriately, small delays in wound debridement do not translate to increased complication rates and waiting for an experienced surgical team is recommended. In cases with no severe tissue damage or contamination, primary wound closure results in lower infection rates and can be recommended. In cases where primary closure is not an option, the wound should be sealed to prevent contamination with nosocomial pathogens.

An open fracture is defined as any fracture accompanied by a break in the skin that communicates with the fracture or its associated haematoma. They are characterised by contamination of the fracture site with microorganisms, and sometimes the introduction of foreign bodies into the wound (Zalavras, 2003). Moreover, depending on the severity of injury, there may be extensive damage to the soft tissue envelope and bone vascularity, which compromises healing potential. As a result, open fractures are associated with an increased risk of complications such as infection and nonunion and present a therapeutic challenge. The incidence of such complications is directly influenced by the emergency treatment approach and as such, the focus of this article is to help practitioners optimise their emergency management of open fractures and minimise complication rates.

The goals of open fracture management are prevention of infection, fracture union and restoration of function. These goals are best achieved by careful patient and injury assessment, including:

Register now to continue reading

Thank you for visiting UK-VET Companion Animal and reading some of our peer-reviewed content for veterinary professionals. To continue reading this article, please register today.