References

Adeyina AO, Oguntoye SO, Olatunde OA, Apata DF. Comparative effects of theobromine and cocoa bean shell (CBS) extract on the performance, serum constituent profile and physiological parameters in rabbits. Global J Pure Appl Sci. 2008; 14:(3)253-255 https://doi.org/10.4314/gjpas.v14i3.16604

Agudelo CF, Filipejova Z, Schanilec ZP. Chocolate ingestion-induced non-cardiogenic pulmonary oedema in a puppy: a case report. Veterinarni Medicina. 2013; 58:(2)109-112 https://doi.org/10.17221/6703-VETMED

Bates N, Rawson-Harris P, Edwards N. Common questions in veterinary toxicology. J Small Anim Pract. 2015; 56:(5)298-306 https://doi.org/10.1111/jsap.12343

Degrandi C, Hermanns-Clausen M, Hofer KE, Reicherta C. Chocolate poisonings in dogs: a consecutive case series [abstract]. Clin Toxicol. 2016; 54:(4) https://doi.org/10.3109/15563650.2016.1165952

Dolder LK. Methylxanthines: caffeine, theobromine and theophylline, 3rd edition. In: Peterson ME, Talcott PA (eds). St Louis: Elsevier; 2013

Drolet R, Arendt TD, Stowe CM. Cacao bean shell poisoning in a dog. J Am Vet Med Assoc. 1984; 185:(8)

Theobromine as undesirable substances in animal feed – scientific opinion of the panel on contaminants in the food chain. EFSA Journal. 2008; 6:(9)1-66 https://doi.org/10.2903/j.efsa.2008.725

Gans JH, Korson R, Cater MR, Ackerly CC. Effects of short-term and long-term theobromine administration to male dogs. Toxicol Appl Pharmacol. 1980; 53:(3)481-496 https://doi.org/10.1016/0041-008x(80)90360-9

Gwaltney-Brant S. Chocolate intoxication. Vet Med. 2001; 96:(2)108-111

Hansen S, Trammel H, Dunayer E, Dwaltney S, Farbman D, Khan S. Cocoa mulch as a cause of methylxanthine toxicosis in dogs. Clin Toxicol. 2003; 41

Hovda LR, Kingston RL. Cocoa bean mulch poisoning in dogs. Vet Hum Toxicol. 1994; 36:(4)

Latini R, Bonati M, Gaspari F Kinetics and metabolism of theobromine in male and female non-pregnant and pregnant rabbits. Toxicology. 1984; 30:(4)343-354 https://doi.org/10.1016/0300-483x(84)90144-6

Possible chocolate poisoning in a dog. 2022. https//tvmdl.tamu.edu/2022/02/24/possible-chocolate-poisoning-in-a-dog/ (accessed 7 October 2023)

McFarland SE, Mischke RH, Hopster-Iversen C Systematic account of animal poisonings in Germany, 2012–2015. Vet Rec. 2017; 180:(13) https://doi.org/10.1136/vr.103973

Miller GE, Radulovic LL, DeWit RH, Brabec MJ, Tarka SM, Cornish HH. Comparative theobromine metabolism in five mammalian species. Drug Metab Dispos. 1984; 12:(2)154-160

Neagu AM, Diac E, Codea AR, Nagy A, Oros A, Dreanca A. Incidence of pet intoxications in the emergency clinic, Faculty of Veterinary Medicine Cluj-Napoca. Bull Uni Agric Sci Vet Med Cluj-Napoca Vet Med. 2021; 78:(1)101-108 https://doi.org/10.15835/buasvmcn-vm2020.0036

Noble PM, Newman J, Wyatt AM, Radford AD, Jones PH. Heightened risk of canine chocolate exposure at Christmas and Easter. Vet Rec. 2017; 181:(25) https://doi.org/10.1136/vr.104762

Soffietti MG, Nebbia C, Valenza F, Amedeo S, Re G. Toxic effects of theobromine on mature and immature male rabbits. J Comp Pathol. 1989; 100:(1)47-58 https://doi.org/10.1016/0021-9975(89)90089-3

Stidworthy MF, Bleakley JS, Cheeseman MT, Kelly DF. Chocolate poisoning in dogs. Vet Rec. 1997; 141:(1)

Stosic A, Ondreka N, Henrich E, Hassdenteufel E, Schneider M. Chocolate intoxication in a dog. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2011; 39:(2)111-115 https://doi.org/10.1055/s-0038-1623569

Strachan ER, Bennett A. Theobromine poisoning in dogs. Vet Rec. 1994; 134:(11) https://doi.org/10.1136/vr.134.11.284

Sutton RH. Cocoa poisoning in a dog. Vet Rec. 1981; 109:(25-26)563-564

Tarka SM, Applebaum RS, Borzelleca JF. Evaluation of the teratogenic potential of cocoa powder and theobromine in New Zealand White rabbits. Food Chem Toxicol. 1986; 24:(5)363-374 https://doi.org/10.1016/0278-6915(86)90200-0

Traina GL, Bonati M. Pharmacokinetics of theobromine and its metabolites in rabbits. J Pharmacokinet Biopharm. 1985; 13:(1)41-53 https://doi.org/10.1007/BF01073655

Weingart C, Hartmann A, Kohn B. Chocolate ingestion in dogs: 156 events (2015–2019). J Small Anim Pract. 2021; 62:(11)979-983 https://doi.org/10.1111/jsap.13329

Chocolate toxicosis in pets

02 December 2023
10 mins read
Volume 28 · Issue 12
Figure 2. Chocolate is available in various forms, as (a) cocoa powder, (b) chocolate bars and (c) boxed chocolates.
Figure 2. Chocolate is available in various forms, as (a) cocoa powder, (b) chocolate bars and (c) boxed chocolates.

Abstract

Chocolate ingestion is very common in pets, particularly dogs, but has also been reported in other animals including cats and rabbits. Most cases occur around Christmas and Easter, when large amounts of chocolate are often present in the home in the form of chocolate bars, snacks, confectionery, Easter eggs and chocolate figurines. Chocolate-covered raisins, nuts and coffee beans present an additional toxicological hazard in dogs. The type of chocolate is defined in law by the percentage of cocoa solids, with dark (plain) chocolate containing more than milk chocolate. The main toxic component of chocolate is theobromine, a methylxanthine, although caffeine, another methylxanthine, is also present. These cause central nervous system stimulation with cardiac and respiratory hyperactivity. Signs include gastrointestinal effects, excitability, hyperactivity, tachycardia, tremors, hypertension and hyperthermia. Signs of toxicosis generally occur within a few hours of ingestion. The mainstays of treatment are decontamination and supportive care with rehydration, control of central nervous system stimulation and arrhythmias as required. Most pets recover fully, and death is uncommon; however, prognosis is more guarded in pets with seizures or arrhythmias.

Chocolate ingestion is very common in pets, particularly in dogs. This article discusses the seasonality, clinical signs and management of chocolate toxicosis in pets.

Chocolate is made from the fermented, dried then roasted beans of Theobroma cacao (Figure 1). After roasting, the shell is removed, and the remaining nibs are ground to cocoa mass which is liquefied to produce chocolate liquor. This can then be processed into cocoa solids and cocoa butter. Cocoa nibs (cacao nibs) are roasted, cracked deshelled beans in broken pieces.

The type of chocolate is defined by the quantity (percentage) of cocoa solids the chocolate contains. Milk chocolate has some of the cocoa solids replaced by milk solids (from dried or condensed milk), giving it a sweeter taste and smoother texture than dark chocolate. In the UK and Ireland, the legal definition for ‘milk chocolate’ differs from that of the rest of Europe. In the UK and Ireland ‘milk chocolate’ must contain a minimum of 20% cocoa solids and 20% milk solids that include at least 5% milk fat. In the rest of Europe, this product is known as ‘family milk chocolate’, while ‘milk chocolate’ needs to have a minimum of 25% cocoa solids and 14% milk solids that include at least 3.5% milk fat.

Register now to continue reading

Thank you for visiting UK-VET Companion Animal and reading some of our peer-reviewed content for veterinary professionals. To continue reading this article, please register today.