References

Ackerman N, Benchekroun G, Bourne D Diabetes mellitus: guidance for managing diabetes in practice. UK-Vet Comp Anim.. 2018; 23:(3)143-151 https://doi.org/10.12968/coan.2018.23.3.143

Asche CV, Shane-McWhorter L, Raparla S Health economics and compliance of vials/syringes versus pen devices: a review of the evidence. Diabetes Technol Ther. 2010; 12:(Suppl 1)S101-S108 https://doi.org/10.1089/dia.2009.0180

Behrend E, Holford A, Lathan P, Rucinsky R, Schulman R 2018 AAHA diabetes management guidelines for dogs and cats. J Am Anim Hosp Assoc.. 2018; 54:(1)1-21 https://doi.org/10.5326/JAAHA-MS-6822

Bennett N, Greco DS, Peterson ME, Kirk C, Mathes M, Fettman MJ Comparison of a low carbohydrate-low fiber diet and a moderate carbohydrate-high fiber diet in the management of feline diabetes mellitus. J Feline Med Surg.. 2006; 8:(2)73-84 https://doi.org/10.1016/j.jfms.2005.08.004

Berg AS, Jacob ME, Mamo LB, Pluta DH, Lunn KF Refrigerated multi-dose insulin vials remain sterile through 6 months of use. J Small Anim Pract.. 2023; 64:(12)776-780 https://doi.org/10.1111/jsap.13664

Borin-Crivellenti S, Bonagura JD, Gilor C Comparison of precision and accuracy of U100 and U40 insulin syringes. J Vet Intern Med.. 2014; 28

Camara A, Verbrugghe A, Cargo-Froom C The daytime feeding frequency affects appetite-regulating hormones, amino acids, physical activity, and respiratory quotient, but not energy expenditure, in adult cats fed regimens for 21 days. PLoS One.. 2020; 15:(9) https://doi.org/10.1371/journal.pone.0238522

Carciofi AC, Takakura FS, de-Oliveira LD Effects of six carbohydrate sources on dog diet digestibility and post-prandial glucose and insulin response. J Anim Physiol Anim Nutr (Berl).. 2008; 92:(3)326-336 https://doi.org/10.1111/j.1439-0396.2007.00794.x

Cobden D, Lee WC, Balu S, Joshi AV, Pashos CL Health outcomes and economic impact of therapy conversion to a biphasic insulin analog pen among privately insured patients with type 2 diabetes mellitus. Pharmacotherapy.. 2007; 27:(7)948-962 https://doi.org/10.1592/phco.27.7.948

Crakes KR, Pires J, Quach N Fenofibrate promotes PPARα-targeted recovery of the intestinal epithelial barrier at the host-microbe interface in dogs with diabetes mellitus. Sci Rep.. 2021; 11:(1) https://doi.org/10.1038/s41598-021-92966-7

Dang DK, Lee J Analysis of symposium articles on insulin pen devices and alternative insulin delivery methods. J Diabetes Sci Technol.. 2010; 4:(3)558-561 https://doi.org/10.1177/193229681000400308

Elliott KF, Rand JS, Fleeman LM A diet lower in digestible carbohydrate results in lower postprandial glucose concentrations compared with a traditional canine diabetes diet and an adult maintenance diet in healthy dogs. Res Vet Sci.. 2012; 93:(1)288-295 https://doi.org/10.1016/j.rvsc.2011.07.032

Fleeman L, Gilor C Insulin therapy in small animals, part 1: general principles. Vet Clin North Am Small Anim Pract.. 2023; 53:(3)615-633 https://doi.org/10.1016/j.cvsm.2023.02.002

Gal A, Odunayo A Diabetes ketoacidosis and hyperosmolar hyperglycemic syndrome in companion animals. Vet Clin North Am Small Anim Pract.. 2023; 53:(3)531-550 https://doi.org/10.1016/j.cvsm.2023.01.005

Gilor C, Graves TK Synthetic insulin analogs and their use in dogs and cats. Vet Clin North Am Small Anim Pract.. 2010; 40:(2)297-307 https://doi.org/10.1016/j.cvsm.2009.11.001

Gilor C, Fleeman LM One hundred years of insulin: is it time for smart?. J Small Anim Pract.. 2022; 63:(9)645-660 https://doi.org/10.1111/jsap.13507

Gilor C, Fracassi F, Berg A, Guarino A, Tardo AM, Fleeman LM Once-daily insulin glargine 300 U/ml for the treatment of canine diabetes mellitus. J Vet Intern Med.. 2022; 36:(6)2277-2278 https://doi.org/10.1111/jvim.16538

Gnanalingham MG, Newland P, Smith CP Accuracy and reproducibility of low dose insulin administration using pen-injectors and syringes. Arch Dis Child.. 1998; 79:(1)59-62 https://doi.org/10.1136/adc.79.1.59

Gostelow R, Forcada Y, Graves T, Church D, Niessen S Systematic review of feline diabetic remission: separating fact from opinion. Vet J.. 2014; 202:(2)208-221 https://doi.org/10.1016/j.tvjl.2014.08.014

Grajower MM, Fraser CG, Holcombe JH How long should insulin be used once a vial is started?. Diabetes Care.. 2003; 26:(9)2665-269 https://doi.org/10.2337/diacare.26.9.2665

Hadd MJ, Bienhoff SE, Little SE Safety and effectiveness of the sodiumglucose cotransporter inhibitor bexagliflozin in cats newly diagnosed with diabetes mellitus. J Vet Intern Med.. 2023; 37:(3)915-924 https://doi.org/10.1111/jvim.16730

Hamilton K, O’Kell AL, Gilor C Serum trypsin-like immunoreactivity in dogs with diabetes mellitus. J Vet Intern Med.. 2021; 35:(4)1713-1719 https://doi.org/10.1111/jvim.16208

Heinemann L, Linkeschova R, Rave K, Hompesch B, Sedlak M, Heise T Timeaction profile of the long-acting insulin analog insulin glargine (HOE901) in comparison with those of NPH insulin and placebo. Diabetes Care.. 2000; 23:(5)644-649 https://doi.org/10.2337/diacare.23.5.644

Heise T, Nosek L, Rønn BB Lower within-subject variability of insulin detemir in comparison to NPH insulin and insulin glargine in people with type 1 diabetes. Diabetes.. 2004; 53:(6)1614-1620 https://doi.org/10.2337/diabetes.53.6.1614

Hill RC, Burrows CF, Bauer JE, Ellison GW, Finke MD, Jones GL Texturized vegetable protein containing indigestible soy carbohydrate affects blood insulin concentrations in dogs fed high fat diets. J Nutr.. 2006; 136:(7 Suppl)2024S-2027S https://doi.org/10.1093/jn/136.7.2024S

Hoenig M, Clark M, Schaeffer DJ, Reiche D Effects of the sodium-glucose cotransporter 2 (SGLT2) inhibitor velagliflozin, a new drug with therapeutic potential to treat diabetes in cats. J Vet Pharmacol Ther.. 2018; 41:(2)266-273 https://doi.org/10.1111/jvp.12467

Jergens AE, Guard BC, Redfern A Microbiota-related changes in unconjugated fecal bile acids are associated with naturally occurring, insulindependent diabetes mellitus in dogs. Front Vet Sci.. 2019; 6 https://doi.org/10.3389/fvets.2019.00199

Keith K, Nicholson D, Rogers D Accuracy and precision of low-dose insulin administration using syringes, pen injectors, and a pump. Clin Pediatr (Phila).. 2004; 43:(1)69-74 https://doi.org/10.1177/000992280404300109

Kim J, Chae Y, Lee D Association between hyperglycemia and canine serum pancreatic lipase immunoreactivity concentration in diabetic dogs. J Am Anim Hosp Assoc.. 2023; 59:(5)241-248 https://doi.org/10.5326/JAAHAMS-7365

Lee YJ, Lee YJ, Han HJ Regulatory mechanisms of Na(+)/glucose cotransporters in renal proximal tubule cells. Kidney Int Suppl. 2007; (106)S27-S35 https://doi.org/10.1038/sj.ki.5002383

Luijf YM, DeVries JH Dosing accuracy of insulin pens versus conventional syringes and vials. Diabetes Technol Ther. 2010; 12:(Suppl 1)S73-S77 https://doi.org/10.1089/dia.2009.0178

Marshall RD, Rand JS, Morton JM Treatment of newly diagnosed diabetic cats with glargine insulin improves glycaemic control and results in higher probability of remission than protamine zinc and lente insulins. J Feline Med Surg.. 2009; 11:(8)683-691 https://doi.org/10.1016/j.jfms.2009.05.016

Mazzaferro EM, Greco DS, Turner AS, Fettman MJ Treatment of feline diabetes mellitus using an alpha-glucosidase inhibitor and a low-carbohydrate diet. J Feline Med Surg.. 2003; 5:(3)183-189 https://doi.org/10.1016/S1098-612X(03)00006-8

How much does insulin cost? Here's how 32 brands and generics compare. 2023. https://www.goodrx.com/healthcare-access/research/how-much-does-insulin-cost-compare-brands

Miller M, Pires J, Crakes K, Greathouse R, Quach N, Gilor C Day-to-day variability of porcine lente, insulin glargine 300 U/mL and insulin degludec in diabetic dogs. J Vet Intern Med.. 2021; 35:(5)2131-2139 https://doi.org/10.1111/jvim.16178

Nack R, DeClue AE In cats with newly diagnosed diabetes mellitus, use of a near-euglycemic management paradigm improves remission rate over a traditional paradigm. Vet Q.. 2014; 34:(3)132-136 https://doi.org/10.1080/01652176.2014.924057

Niessen SJM Hypersomatotropism and other causes of insulin resistance in cats. Vet Clin North Am Small Anim Pract.. 2023; 53:(3)691-710 https://doi.org/10.1016/j.cvsm.2023.02.005

Niessen SJM, Hazuchova K, Powney SL The big pet diabetes survey: perceived frequency and triggers for euthanasia. Vet Sci.. 2017; 4:(2) https://doi.org/10.3390/vetsci4020027

Niessen SJM, Bjornvad C, Church DB Agreeing language in veterinary endocrinology (ALIVE): diabetes mellitus - a modified Delphi-method-based system to create consensus disease definitions. Vet J.. 2022; 289 https://doi.org/10.1016/j.tvjl.2022.105910

Oda H, Mori A, Ishii S, Shono S, Onozawa E, Sako T Time-action profiles of insulin degludec in healthy dogs and its effects on glycemic control in diabetic dogs. J Vet Med Sci.. 2018; 80:(11)1720-1723 https://doi.org/10.1292/jvms.17-0714

Owens DR, Bolli GB Beyond the era of NPH insulin—long-acting insulin analogs: chemistry, comparative pharmacology, and clinical application. Diabetes Technol Ther.. 2008; 10:(5)333-349 https://doi.org/10.1089/dia.2008.0023

Parker VJ, Hill RC Nutritional management of cats and dogs with diabetes mellitus. Vet Clin North Am Small Anim Pract.. 2023; 53:(3)657-674 https://doi.org/10.1016/j.cvsm.2023.01.007

Pendsey S, James S, Garrett TJ Insulin thermostability in a real-world setting. Lancet Diabetes Endocrinol.. 2023; 11:(5)310-312 https://doi.org/10.1016/S2213-8587(23)00028-1

Pfützner A FlexPen for the delivery of insulin: accuracy, injection force and patient preference. Expert Rev Med Devices.. 2009; 6:(2)115-123 https://doi.org/10.1586/17434440.6.2.115

Restine LM, Norsworthy GD, Kass PH Loose-control of diabetes mellitus with protamine zinc insulin in cats: 185 cases (2005–2015). Can Vet J.. 2019; 60:(4)399-404

Roomp K, Rand J Intensive blood glucose control is safe and effective in diabetic cats using home monitoring and treatment with glargine. J Feline Med Surg.. 2009; 11:(8)668-682 https://doi.org/10.1016/j.jfms.2009.04.010

Roomp K, Rand J Evaluation of detemir in diabetic cats managed with a protocol for intensive blood glucose control. J Feline Med Surg.. 2012; 14:(8)566-572 https://doi.org/10.1177/1098612X12446211

Rothlin-Zachrisson N, Öhlund M, Röcklinsberg H, Ström Holst B Survival, remission, and quality of life in diabetic cats. J Vet Intern Med.. 2023; 37:(1)58-69 https://doi.org/10.1111/jvim.16625

Rudloff E Diabetic ketoacidosis in the cat: recognition and essential treatment. J Feline Med Surg.. 2017; 19:(11)1167-1174 https://doi.org/10.1177/1098612X17735762

Saini NK, Wasik B, Pires J Comparison of pharmacodynamics between insulin glargine 100 U/mL and insulin glargine 300 U/mL in healthy cats. Domest Anim Endocrinol.. 2021; 75 https://doi.org/10.1016/j.domaniend.2020.106595

Sako T, Mori A, Lee P Time-action profiles of insulin detemir in normal and diabetic dogs. Res Vet Sci.. 2011; 90:(3)396-403 https://doi.org/10.1016/j.rvsc.2010.07.001

Shiel RE, Mooney CT Insulins for the long term management of diabetes mellitus in dogs: a review. Canine Med Genet.. 2022; 9:(1) https://doi.org/10.1186/s40575-022-00114-9

Tardo AM, Del Baldo F, Dondi F, Pietra M, Chiocchetti R, Fracassi F Survival estimates and outcome predictors in dogs with newly diagnosed diabetes mellitus treated in a veterinary teaching hospital. Vet Rec.. 2019; 185:(22) https://doi.org/10.1136/vr.105227

Thompson A, Lathan P, Fleeman L Update on insulin treatment for dogs and cats: insulin dosing pens and more. Vet Med (Auckl).. 2015; 6:129-142 https://doi.org/10.2147/VMRR.S39984

Improving owner compliance with therapy of canine and feline diabetes: the American perspective

02 April 2025
16 mins read
Volume 30 · Issue 4
Figure 1. 
Realistic goals of therapy for dogs and cats with diabetes mellitus. Adapted from Niessen et al (2022).
Figure 1. Realistic goals of therapy for dogs and cats with diabetes mellitus. Adapted from Niessen et al (2022).

Abstract

Diabetes mellitus in dogs and cats presents unique challenges for pet owners, often resulting in treatment failure and decreased survival rates. However, there are strategies to enhance compliance with therapy and improve the quality of life for both pets and owners. Rather than focusing on tight glycaemic control, the realistic goals for diabetes therapy are based on owner and pet quality of life, prevention of diabetic ketoacidosis, hypoglycaemia and other diabetic complications and normalisation of body condition score. Selection of insulin should be individualised, with factors such as cost, time-action profile and available form considered. Insulin pens can be a valuable tool for improving accuracy and precision of insulin administration, especially at low doses. Insulin cost can vary greatly between countries, which can also impact treatment decisions. For diabetic dogs with finicky appetites or the ‘miniature’ patient, basal insulin therapy can be an effective solution. Reducing the dietary carbohydrate content in feline patients often reduces their insulin requirements. Sodium glucose cotransporter-2 inhibitors offer an exciting new oral option and insulin alternative for newly diagnosed healthy cats in the USA. By tailoring diabetes therapy to the individual pet and owner, veterinarians can improve treatment outcomes, compliance and quality of life.

Although diabetes mellitus is a chronic and treatable disease, it is often associated with relatively short survival times in dogs and cats (Niessen et al, 2017; Tardo et al, 2019; Rothlin‐Zachrisson et al, 2023). Approximately 1 in 10 diabetic dogs and cats are euthanised at the time of diagnosis, and an additional 1 in 10 within the first year of therapy (Niessen et al, 2017). Treatment failures commonly arise from temporary or more permanent compliance challenges and frustrations by pet owners. Specifically, the necessity for sustaining a consistent schedule over years can have a negative impact on an owner's quality of life, especially in patients with inconsistent appetite. Pet owners can experience many obstacles to management of their pet's diabetes, such as lifestyle adjustments, unrealistic expectations, financial burden, concerns about potential complications and inability to administer insulin injections. The financial and time commitments can become overwhelming. Frequent veterinary monitoring of glycaemic control and high insulin cost in some geographic locations contribute to these stresses (Niessen et al, 2017). However, there are simple and practical solutions to long-term compliance issues with regards to therapy that can, and should, be implemented by the veterinary practitioner. These require an understanding of diabetes-related pathophysiology, pharmacology and clinical pathology, understanding of general goals of treatments and, critically, a thorough discussion with pet owners about their goals and abilities.

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