References

Angelo KM, Reynolds J, Karp B Antimicrobial resistance among nontyphoidal Salmonella isolated from blood in the United States, 2003–2013. J Infect Dis. 2016; 214:(10)1565-1570 https://doi.org/10.1093/infdis/jiw415

Animals and Plant Health Agency. Salmonella in livestock production in GB. 2018. https://webarchive.nationalarchives.gov.uk/20200803212253/ (accessed 22 February, 2021)

Baede V, Broens E, Spaninks M Raw pet food as a risk factor for shedding of extended-spectrum beta-lactamase-producing Enterobacteriaceae in household cats. PLoS One. 2017; 12:(11) https://doi.org/10.1371/journal.pone.0187239

Baede V, Wagenaar J, Broens E Longitudinal study of extended-spectrum-β-lactamase- and AmpC-producing Enterobacteriaceae in household dogs. Antimicrob Agents Chemother. 2015; 59:(6)3117-3124 https://doi.org/10.1128/AAC.04576-14

BARF World. The benefits of the BARF world diet. 2021. https://www.barfworld.com/blog/the-benefits-of-the-barf-world-diet (accessed 25 January 2021)

Botsch V, Küchenhoff H, Hartmann K, Hirschberger J. Retrospective study of 871 dogs with thrombocytopenia. Vet Rec. 2009; 164:(21)647-651 https://doi.org/10.1136/vr.164.21.647

Bucher M, Meyer C, Grötzbach B Epidemiological data on pathogenic Yersinia enterocolitica in southern Germany during 2000-2006. Foodborne Pathog Dis. 2008; 5:(3)273-280 https://doi.org/10.1089/fpd.2007.0076

Investigation into an outbreak of Shiga toxin producing Escherichia coli, August 2017. 2018. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/765498/STEC_O157_PT21.28_Outbreak_Report.pdf (accessed 22 February 2021)

Chirek A, Silaghi C, Pfister K, Kohn B. Granulocytic anaplasmosis in 63 dogs: clinical signs, laboratory results, therapy and course of disease. J Small Anim Pract. 2018; 59:(2)112-120 https://doi.org/10.1111/jsap.12787

Coelho W, Amarante A, Apolinário J Seroepidemiology of Toxoplasma gondii, Neospora caninum, and Leishmania spp. infections and risk factors for cats from Brazil. Parasitol Res. 2011; 109:(4)1009-1013 https://doi.org/10.1007/s00436-011-2461-x

Cortese L, Sica M, Piantedosi D Secondary immune-mediated thrombocytopenia in dogs naturally infected by Leishmania infantum. Vet Rec. 2009; 164:(25)778-782 https://doi.org/10.1136/vr.164.25.778

Crump JA, Sjölund-Karlsson M, Gordon MA, Parry CM. Epidemiology, clinical presentation, laboratory diagnosis, antimicrobial resistance, and antimicrobial management of invasive salmonella infections. Clin Microbiol Rev. 2015; 28:(4)901-937 https://doi.org/10.1128/CMR.00002-15

Davies R, Lawes J, Wales A. Raw diets for dogs and cats: a review, with particular reference to microbiological hazards. J Small Anim Pract. 2019; 60:(6)329-339 https://doi.org/10.1111/jsap.13000

Duijvestijn M, Mughini-Gras L, Schuurman N Enteropathogen infections in canine puppies: (co-)occurrence, clinical relevance and risk factors. Vet Microbiol. 2016; 195:115-122 https://doi.org/10.1016/j.vetmic.2016.09.006

Finley R, Reid-Smith R, Ribble C The occurrence and antimicrobial susceptibility of salmonellae isolated from commercially available canine raw food diets in three Canadian cities. Zoonoses Public Health. 2008; 55:(8-10)462-469 https://doi.org/10.1111/j.1863-2378.2008.01147.x

França RT, Pillat MM, Silva CB Surface immunoglobulins of erythrocytes and platelets in dogs naturally infected by Rangelia vitalii. Microb Pathog. 2018; 121:245-251 https://doi.org/10.1016/j.micpath.2018.05.036

Freeman L, Michel K. Evaluation of raw food diets for dogs. J Am Vet Med Assoc. 2001; 218:(5)705-709 https://doi.org/10.2460/javma.2001.218.705

Freeman L, Chandler M, Hamper B, Weeth LP. Current knowledge about the risks and benefits of raw meat based diets for dogs and cats. J Am Vet Med Assoc. 2013; 243:(11)1549-1558 https://doi.org/10.2460/javma.243.11.1549

Frost A. Feeding of raw Brucella suis-infected meat to dogs in the UK. Vet Rec. 2017; 181 https://doi.org/10.1136/vr.j4972

Role of diet in the health of the feline intestinal tract and in inflammatory bowel disease. 2002. https://ccah.vetmed.ucdavis.edu/sites/g/files/dgvnsk4586/files/inline-files/role-of-diet-feline-health-Glasgow_0.pdf (accessed 22 February 2021)

Greene CE. Enteric bacterial infections, 4th edn. In: Sykes J, Greene CE (eds). St. Louis MO: Elsevier; 2011

Greiner M, Wolf G, Hartmann K. A retrospective study of the clinical presentation of 140 dogs and 39 cats with bacteraemia. J Small Anim Pract. 2008; 49:(8)378-383 https://doi.org/10.1111/j.1748-5827.2008.00546.x

Hamper B, Bartges J, Kirk C. Evaluation of two raw diets vs a commercial cooked diet on feline growth. J Feline Med Surg. 2017; 19:(4)424-434 https://doi.org/10.1177/1098612X16634388

Hellgren J, Hästö L, Wikström C, Fernström LL, Hansson I. Occurrence of Salmonella, Campylobacter, Clostridium and Enterobacteriaceae in raw meat-based diets for dogs. Vet Rec. 2019; 184:(14)442-442 https://doi.org/10.1136/vr.105199

Jo'neill E, Acke E, Tobin E, McCarthy G. Immune-mediated thrombocytopenia associated with Angiostrongylus vasorum infection in a Jack Russell Terrier. Ir Vet J. 2010; 63:(7)434-440 https://doi.org/10.1186/2046-0481-63-7-434

Lambertini E, Buchanan R, Narrod C, Pradhan AK. Transmission of bacterial zoonotic pathogens between pets and humans: the role of pet food. Crit Rev Food Sci Nutr. 2016; 56:(3)364-418 https://doi.org/10.1080/10408398.2014.902356

Leahy A, Cummings K, Rodriguez-Rivera L, Hamer SA, Lawhon SD. Faecal Campylobacter shedding among dogs in animal shelters across Texas. Zoonoses Public Health. 2017; 64:(8)623-627 https://doi.org/10.1111/zph.12356

Lefebvre SL, Reid-Smith R, Boerlin P, Weese JS. Evaluation of the risks of shedding Salmonellae and other potential pathogens by therapy dogs fed raw diets in Ontario and Alberta. Zoonoses Public Health. 2008; 55:(8–10)470-480 https://doi.org/10.1111/j.1863-2378.2008.01145.x

LeJeune J, Hancock D. Public health concerns associated with feeding raw meat diets to dogs. J Am Vet Med Assoc. 2001; 219:(9)1222-1225 https://doi.org/10.2460/javma.2001.219.1222

Lenox C, Becvarova I, Archipow W. Metabolic bone disease and central retinal degeneration in a kitten due to nutritional inadequacy of an all-meat raw diet. JFMS Open Rep. 2015; 1:1-5 https://doi.org/10.1177/2055116915579682

Leonard E, Pearl D, Janecko N Risk factors for carriage of antimicrobial-resistant Salmonella spp and Escherichia coli in pet dogs from volunteer households in Ontario, Canada, in 2005 and 2006. Am J Vet Res. 2015; 76:(11)959-968 https://doi.org/10.2460/ajvr.76.11.959

Lopes A, Cardoso L, Rodrigues M. Serological survey of Toxoplasma gondii infection in domestic cats from northeastern Portugal. Vet Parasitol. 2008; 155:(3–4)184-189 https://doi.org/10.1016/j.vetpar.2008.05.007

Macpherson C. Human behaviour and the epidemiology of parasitic zoonoses. Int J Parasitol. 2005; 35:(11–12)1319-1331 https://doi.org/10.1016/j.ijpara.2005.06.004

Mehlenbacher S, Churchill J, Olsen K, Bender JB. Availability, brands, labelling and Salmonella contamination of raw pet food in the Minneapolis/St. Paul area. Zoonoses Public Health. 2012; 59:(7)513-520 https://doi.org/10.1111/j.1863-2378.2012.01491.x

Morley P, Strohmeyer R, Tankson J Evaluation of the association between feeding raw meat and Salmonella enterica infections at a greyhound breeding facility. J Am Vet Med Assoc. 2006; 228:(10)1524-1532 https://doi.org/10.2460/javma.228.10.1524

Natures Menu. Benefits of feeding your pet raw food. 2020. https://www.naturesmenu.co.uk/raw-benefits (accessed 25 January 2021)

Nemser S, Doran T, Grabenstein M Investigation of Listeria, Salmonella, and toxigenic Escherichia coli in various pet foods. Foodborne Pathog Dis. 2014; 11:(9)706-709 https://doi.org/10.1089/fpd.2014.1748

O'Halloran C, Gunn-Moore D, Reed N Mycobacterium bovis in pet cats. Vet Rec. 2018; 183

O'Marra S, Delaforcade A, Shaw S. Treatment and predictors of outcome in dogs with immune-mediated thrombocytopenia. J Am Vet Med Assoc. 2011; 238:(3)346-352 https://doi.org/10.2460/javma.238.3.346

Overgaauw P, van Zutphen L, Hoek D Zoonotic parasites in fecal samples and fur from dogs and cats in The Netherlands. Vet Parasitol. 2009; 163:(1–2)115-122 https://doi.org/10.1016/j.vetpar.2009.03.044

Plumb DC. Plumb's veterinary drug handbook, 9th edn. Stockholm (WI): PharmaVet Inc; 2018

Saha S, Sajib M, Garrett D, Qamar FN. Antimicrobial resistance in Typhoidal Salmonella: around the world in 3 days. Clin Infect Dis. 2020; 71:S91-S95 https://doi.org/10.1093/cid/ciaa366

Sandri M, Dal Monego S, Conte G, Sgorlon S, Stefanon B. Raw meat based diet influences faecal microbiome and end products of fermentation in healthy dogs. BMC Vet Res. 2017; 13 https://doi.org/10.1186/s12917-017-0981-z

Schmidt V, Pinchbeck G, Nuttall T Antimicrobial resistance risk factors and characterisation of faecal E. coli isolated from healthy Labrador retrievers in the United Kingdom. Prev Vet Med. 2015; 119:(1–2)31-40 https://doi.org/10.1016/j.prevetmed.2015.01.013

Silva R, Machado G. Canine neosporosis: perspectives on pathogenesis and management. Vet Med (Auckl). 2016; 7:59-70 https://doi.org/10.2147/VMRR.S76969

Strohmeyer R, Morley P, Hyatt D Evaluation of bacterial and protozoal contamination of commercially available raw meat diets for dogs. J Am Vet Med Assoc. 2006; 228:(4)537-542 https://doi.org/10.2460/javma.228.4.537

van Bree F, Bokken G, Mineur R Zoonotic bacteria and parasites found in raw meat-based diets for cats and dogs. Vet Rec. 2018; 182:(2)50-50 https://doi.org/10.1136/vr.104535

Viegas F, Ramos C, Xavier R Fecal shedding of Salmonella spp., Clostridium perfringens, and Clostridioides difficile in dogs fed raw meat-based diets in Brazil and their owners' motivation. PLoS One. 2020; 15:(4) https://doi.org/10.1371/journal.pone.0231275

Waters A. Raw diets: are we at a turning point?. Vet Rec. 2017; 181:384-384

Wedley AL, Dawson S, Maddox TW Carriage of antimicrobial resistant Escherichia coli in dogs: prevalence, associated risk factors and molecular characteristics. Vet Microbiol. 2017; 199:23-30 https://doi.org/10.1016/j.vetmic.2016.11.017

Weese J, Rousseau J. Survival of Salmonella Copenhagen in food bowls following contamination with experimentally inoculated raw meat: effects of time, cleaning, and disinfection. Can Vet J. 2006; 47:(9)887-889

Septicaemia and thrombocytopenia caused by Salmonella gallinarum in a dog fed a raw meat-based diet

02 April 2021
11 mins read
Volume 26 · Issue 4

Abstract

In recent years, it has become increasingly popular for pet owners to feed their dogs and cats raw meat as an alternative to processed, manufactured diets. Owners are often unaware of the potential risks this may pose for their animals and for themselves, despite the published literature. This article reports the case of a 5-month-old female French Bulldog referred for investigation of acute vomiting, diarrhoea and pyrexia. She was diagnosed with septicaemia, associated with Salmonella gallinarum (identified on blood culture), as well as a positive faecal culture for Campylobacter coli and severe thrombocytopenia (presumably secondary to infection). She received supportive treatment and marbofloxacin, going on to make a full recovery. Considering the Salmonella serovar identified (which is host-specific to poultry) and the animal's lifestyle, it is possible the septicaemia originated from her raw meat diet. Salmonella spp. is potentially zoonotic and can cause acute enteritis in humans. This is the first report of septicaemia with positive blood culture for Salmonella gallinarum, with secondary severe thrombocytopenia (presumably immune-mediated), in a dog that was fed a raw meat diet.

There has been a recent trend in developed countries such as the UK, of feeding dogs and cats raw meat-based diets (Waters, 2017). Investigations of the nutritional value of such diets have suggested that they pose the risk of nutrient imbalances and vitamin deficiencies (Freeman and Michel, 2001; Freeman et al, 2013; Lenox et al, 2015). A topic often discussed is the risk to human and animal health from contamination or infection of raw meat with parasites and zoonotic bacteria, including antimicrobial-resistant bacteria.

Surveillance of Salmonella spp. in pet diets by the Animal and Plant Health Agency in the UK has shown that raw meat diets are 20 times more likely to be positive for Salmonella spp. than processed diets (Animals and Plant Health Agency, 2018). In Brazil, dogs fed raw meat-based diets were 30 times more likely to be positive for Salmonella than dogs on processed diets. Some of the serovars that were isolated are commonly associated with human salmonellosis, and 88% of the isolates were resistant to at least one of the seven classes of antimicrobials tested (Viegas et al, 2020).

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